Yes, you can restrict destinations in most cases, but it depends on how your portal is set up and what rules you want to enforce. Some travel businesses need to limit their agents to certain regions or countries for compliance reasons, budget control, or because they only have contracts with suppliers in those areas. Your portal can be configured to show only the destinations you choose, which means your agents will only see search results and availability for those places when they log in.
The way this works in practice varies depending on your setup. If you are using a standard configuration, you can usually control which destinations appear in the dropdown menus and search filters that your agents see. This is a straightforward way to guide them towards the regions you want them to focus on. However, if you need more complex rules, like allowing certain agents to book in more destinations than others, or blocking specific countries while allowing others, you should check with your portal provider about what is possible under your particular plan and configuration.
Keep in mind that destination restrictions are different from price markups or commission rates. You might want some agents to access everywhere but earn different commissions depending on where they book, or you might want to completely hide certain destinations from certain agents. The level of control available to you will depend on the features included in your white label setup. Check with your provider about which restriction options are available to you and how they can be customized for your business needs.