Yes, you can search the flight API to see what airlines and routes are available, but keep in mind that the results you see when you search will depend on the suppliers the API is connected to and the search filters you use. When you are setting up your portal, you can run test searches for the routes your customers are most likely to book, and that will give you a good idea of which airlines appear regularly and what kind of fares are on offer. This helps you plan your marketing and decide which routes to highlight on your homepage.
One thing to understand is that the availability you see in a test search may change by the time your actual customers start booking. Flight schedules get updated, airlines add or remove flights, and fares go up and down all the time. So even if you see a particular airline on a popular route today, there is no guarantee it will always be there. The API will show you whatever is available at the moment your customer searches, which is what matters when they are actually ready to book.
You should also know that some airlines may not be on the API at all, depending on how the suppliers are set up. If there are specific airlines you want to offer to your customers, check with us about whether they are included before you launch your portal. Run a few test searches on the routes that matter most to your business, and that will tell you whether you are getting the selection you need.