Can I run my white label travel portal on my own domain name?

Yes, your white label travel portal can run on your own domain name, so your customers never see anyone else's web address while they search and book.

In practice you keep buying and owning the domain yourself, and you point it at the portal by making a small change with the company you bought it from. You can use your main web address if you do not have another site sitting there, or a booking subdomain if your existing website is built elsewhere and you only want the booking part on the portal. A security certificate is set up for whichever address you choose, so the padlock and the secure prefix show as normal.

There are a few honest limits. You need to own the domain and be able to get into its settings, or have someone who can, because that change has to be made on your side. Once it is made, it takes a little while to spread across the internet, so the new address may not work everywhere at the same moment. Some steps may still pass through an address that is not yours, for example a payment page hosted by your payment provider or an airline page for check in, and that is normal and safe. Sending your booking emails from your own domain is a separate setup with its own records.

Before you start, find out who holds the login for your domain settings, and decide whether you want the portal on your main address or on a booking subdomain, because that choice is much easier to make now than to change later.